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Proton magnetic resonance spectroscopy of a gray matter heterotopia
L Marsh1, K O Lim, E V Sullivan
1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5546, USA.
Abstract:
We used proton magnetic resonance spectroscopy to examine resonances representing metabolites containing N-acetyl (NA) groups (predominantly N-acetyl aspartate), choline, and creatine within a large left-hemispheric gray matter heterotopia (GMH) in a 35-year-old man with corpus callosum agenesis. In contrast to normal brain tissue, including gray matter regions, heterotopic gray matter was characterized by relatively increased choline and creatine resonances and a normal NA signal. These data suggest increased cellular activity or persistent immature neuronal tissue in GMH relative to unaffected tissue.