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Antioxidant status in experimental hyperthyroidism: effect of vitamin E supplementation
1Department of Biochemistry, Cerrahpaşa Medical Faculty, Istanbul University, Turkey.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 9, 1996
Summary
Hyperthyroidism elevates erythrocyte antioxidant systems, including superoxide dismutase and glutathione. Vitamin E supplementation mitigates this oxidative stress in hyperthyroid rats.
Area of Science:
- Biochemistry
- Endocrinology
- Oxidative Stress Research
Background:
- Oxidative stress is linked to degenerative diseases.
- Hyperthyroidism involves oxidative processes.
- Erythrocytes are crucial in antioxidant defense.
Purpose of the Study:
- Investigate erythrocyte antioxidant status in experimental hyperthyroidism.
- Evaluate the impact of vitamin E on antioxidant defense systems in hyperthyroidism.
Main Methods:
- Induction of hyperthyroidism in rats using thyroxine administration.
- Measurement of thyroid hormones (T4, T3) and thyroid-stimulating hormone (TSH).
- Assay of erythrocyte antioxidant enzymes: superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and glutathione (GSH) levels.
Main Results:
- Hyperthyroidism confirmed by elevated T4/T3 and undetectable TSH.
- Significantly increased SOD, GSH-Px, and GSH in hyperthyroid rats versus controls.
- Vitamin E supplementation decreased GSH-Px activity and increased GSH levels in hyperthyroid rats.
Conclusions:
- Hyperthyroidism enhances erythrocyte antioxidant system components.
- Vitamin E supplementation ameliorates oxidative stress in hyperthyroidism.
- Erythrocyte antioxidant status is a key factor in hyperthyroid oxidative stress.