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Related Experiment Videos

Protein C activation in NIDDM patients

E C Gabazza1, H Takeya, H Deguchi

  • 1Department of Molecular Pathobiology, Mie University School of Medicine, Japan.

Diabetologia
|December 1, 1996
PubMed
Summary

Diabetic patients show increased clotting activation, with higher protein C activation but reduced response to thrombomodulin. This suggests a hyper-coagulable state linked to impaired anticoagulant pathways in diabetes mellitus.

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Area of Science:

  • Biochemistry
  • Hematology
  • Endocrinology

Background:

  • Enhanced clotting system activation is linked to vascular complications in diabetes mellitus.
  • Anticoagulant system abnormalities may trigger hemostatic activation in diabetic subjects.

Purpose of the Study:

  • To evaluate anticoagulant activity in diabetic patients.
  • To assess plasma levels of activated protein C-protein C inhibitor complex.
  • To measure the anticoagulant response to exogenous thrombomodulin.

Main Methods:

  • Study included 61 non-insulin-dependent diabetes mellitus (NIDDM) patients and 31 healthy controls.
  • Measured plasma levels of fibrinogen, prothrombin fragment 1+2, fibrin monomer, protein C antigen, protein S antigen, soluble thrombomodulin, and soluble E-selectin.

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  • Assessed plasma levels of activated protein C-protein C inhibitor complex and anticoagulant response to exogenous thrombomodulin.

    • Main Results:

    • Diabetic patients exhibited higher levels of clotting factors and markers of activation compared to controls.
    • Plasma levels of activated protein C-protein C inhibitor complex were significantly higher in diabetics.
    • Diabetic patients showed a markedly lower anticoagulant response to exogenous thrombomodulin.
    • Microalbuminuric diabetic patients had lower activated protein C-protein C inhibitor complex and a reduced response to thrombomodulin compared to normoalbuminuric patients.

    Conclusions:

    • The hyper-coagulable state in NIDDM is associated with increased protein C activation.
    • Diabetic patients demonstrate a diminished plasma reactivity to the anticoagulant effects of thrombomodulin.
    • These findings highlight potential dysregulation of the anticoagulant system in diabetes-related vascular complications.