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Related Experiment Videos

Glomerular hyperfiltration in microalbuminuric NIDDM patients

P Vedel1, J Obel, F S Nielsen

  • 1Steno Diabetes Center, Gentofte, Denmark.

Diabetologia
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

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Glomerular hyperfiltration, an elevated kidney filtration rate, is prevalent in microalbuminuric patients with non-insulin-dependent diabetes mellitus (NIDDM). This finding suggests hyperfiltration is a risk factor for diabetic nephropathy progression in these patients.

Area of Science:

  • Nephrology
  • Diabetology
  • Internal Medicine

Background:

  • Diabetic nephropathy is a major complication of diabetes mellitus.
  • Microalbuminuria and glomerular hyperfiltration are recognized risk factors for diabetic nephropathy.
  • Limited data exists on glomerular hyperfiltration in microalbuminuric non-insulin-dependent diabetes mellitus (NIDDM) patients.

Purpose of the Study:

  • To investigate the prevalence of glomerular hyperfiltration in microalbuminuric NIDDM patients.
  • To compare glomerular filtration rates (GFR) between microalbuminuric NIDDM patients, normoalbuminuric NIDDM patients, and non-diabetic controls.

Main Methods:

  • Cross-sectional study involving 158 microalbuminuric NIDDM patients, 39 normoalbuminuric NIDDM patients, and 20 non-diabetic controls.

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  • Glomerular filtration rate was measured using 51Cr-EDTA single intravenous bolus injection and 4-hour plasma clearance.
  • Groups were matched for sex, age, and body mass index.

    • Main Results:

    • Glomerular filtration rate was significantly elevated in microalbuminuric NIDDM patients compared to normoalbuminuric NIDDM patients and controls (p < 0.001).
    • Glomerular hyperfiltration was identified in 37% of microalbuminuric NIDDM patients.
    • HbA1c, 24-hour urinary sodium excretion, age, and diabetes duration correlated with GFR in microalbuminuric NIDDM patients (r2 = 0.21, p < 0.01).

    Conclusions:

    • Microalbuminuric NIDDM patients exhibit a high prevalence of glomerular hyperfiltration.
    • Glomerular hyperfiltration represents an additional risk factor for diabetic nephropathy progression in NIDDM patients.
    • Further research is warranted to explore the clinical implications of hyperfiltration in NIDDM.