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Hypertriglyceridemia, but not hypercholesterolemia, is associated with the alterations of fibrinolytic system
T Hiraga1, M Shimada, T Tsukada
1Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Insights
Hypertriglyceridemia, not high cholesterol, is linked to changes in the blood
Area of Science:
- Cardiovascular Science
- Hematology
- Metabolic Disorders
Background:
- Blood coagulation and fibrinolysis are crucial for cardiovascular health.
- Alterations in these systems are linked to atherosclerosis, but data in individuals without complications is limited.
Purpose of the Study:
- To investigate the relationship between lipid profiles and fibrinolytic parameters in hyperlipoproteinemia.
- To assess the thrombotic risk associated with different types of hyperlipoproteinemia.
Main Methods:
- Examined serum lipid levels and fibrinolytic parameters (tissue-type plasminogen activator and plasminogen activator inhibitor-1) in 54 hyperlipoproteinemia patients and 18 controls.
- Analyzed correlations between lipid concentrations and fibrinolytic markers.
Main Results:
- Type IV hyperlipoproteinemia showed significantly higher plasma tissue-type plasminogen activator and plasminogen activator inhibitor-1 levels compared to controls.
- Serum triglyceride levels positively correlated with tissue-type plasminogen activator and plasminogen activator inhibitor-1.
- Serum cholesterol levels did not show a significant correlation with these fibrinolytic parameters.
Conclusions:
- Hypertriglyceridemia is associated with alterations in the fibrinolytic system.
- Hypercholesterolemia is not directly linked to these specific fibrinolytic changes.
- Findings suggest hypertriglyceridemia may contribute to thrombotic risk through fibrinolytic system derangements.
Abstract:
Derangements of the blood coagulation-fibrinolytic system are thought to be associated with the development of cardiovascular disease. Previous studies have identified the alterations in patients with advanced atherosclerosis, however, studies on subjects without apparent cardiovascular complications are scarce. To evaluate the potential risk of thrombosis, we examined the serum lipid levels and fibrinolytic parameters in 54 subjects of different types of primary hyperlipoproteinemia (HL) and 18 normolipidemic controls. Plasma tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) antigen levels were significantly higher in type IV HL than in the controls. Serum triglyceride concentrations were correlated with t-PA (r = 0.537, p < 0.01) and PAI-1 (r = 0.249, p < 0.05) antigen levels, while serum cholesterol levels did not. The current study demonstrated that hypertriglyceridemia, but not hypercholesterolemia, is associated with the alterations of fibrinolytic system.