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An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers
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Published on: December 1, 2017

Annual influenza vaccination: immune response in patients over 10 years

P A Gross1, C R Denning, P F Gaerlan

  • 1Department of Internal Medicine, Hackensack University Medical Center, NJ, USA.

Vaccine
|September 1, 1996
PubMed

Insights

Annual influenza immunization in cystic fibrosis (CF) patients consistently generates protective antibody levels. This 10-year study found no significant change in antibody titers or Shwachman scores, indicating sustained vaccine effectiveness.

Area of Science:

  • Immunology
  • Pediatrics
  • Pulmonology

Background:

  • Cystic Fibrosis (CF) patients face increased risk from influenza.
  • Annual influenza vaccination is recommended for individuals with CF.
  • The long-term impact of repeated influenza immunization on antibody response in CF patients is not well-defined.

Purpose of the Study:

  • To evaluate the effect of repeated annual influenza immunization on serum antibody levels in children and young adults with CF.
  • To assess the durability of the immune response to influenza vaccination over a 10-year period in this population.

Main Methods:

  • A 10-year observational cohort study was conducted.
  • Thirty-eight children and young adults with CF were included.
  • Serum hemagglutination inhibition (HI) antibody titers were measured annually pre- and post-vaccination.

Main Results:

  • No significant upward or downward trend in geometric mean serum HI antibody titers was observed over 10 years.
  • The majority of participants achieved presumably protective antibody titers (≥1:40) annually for all tested influenza strains (A/H3N2, A/H1N1, B).
  • Mean Shwachman scores remained stable, with no significant difference between the initial and final scores (77 vs. 76).

Conclusions:

  • Repeated annual influenza vaccination effectively induces protective serum antibody levels in most children and young adults with CF.
  • The study suggests sustained immunogenicity and clinical stability associated with annual influenza immunization in this cohort over a decade.
Abstract

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