Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Hypercalcemia and systemic lupus erythematosus

L J Deftos¹, D W Burton, S M Baird

¹Department of Medicine, University of California, San Diego, USA.

Arthritis and Rheumatism

|December 1, 1996

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Determination of Whole-Cell Fatty Acid Profiles for the Characterization and Differentiation of Isolates of Rhizoctonia solani AG-4 And AG-7.

Plant disease·2019

Same author

Occidiofungin is an important component responsible for the antifungal activity of Burkholderia pyrrocinia strain Lyc2.

Journal of applied microbiology·2016

Same author

Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis.

Annals of the rheumatic diseases·2009

Same author

Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA.

Osteoarthritis and cartilage·2009

Same author

Nematode population and community dynamics in soybean-wheat cropping and tillage regimes.

Journal of nematology·2009

Same author

Calcification of human articular knee cartilage is primarily an effect of aging rather than osteoarthritis.

Osteoarthritis and cartilage·2007

Increased parathyroid hormone-related protein (PTHrP) typically signals cancer. However, this study found non-malignant lupus lymph nodes can also produce PTHrP, causing hypercalcemia.

Area of Science:

Endocrinology
Immunology
Oncology

Background:

Hypercalcemia is often linked to malignancy-induced parathyroid hormone-related protein (PTHrP) overproduction.
Elevated PTHrP levels in hypercalcemic patients are considered a strong indicator of cancer.

Observation:

A patient with systemic lupus erythematosus (SLE), generalized lymphadenopathy, and hypercalcemia was investigated.
Immunohistology of lymph node biopsies showed abundant PTHrP expression.
No evidence of malignant transformation was found in the biopsied lymph nodes.

Findings:

The study identified PTHrP production in non-malignant lymphoid tissue associated with SLE.
This finding challenges the assumption that PTHrP-mediated hypercalcemia is exclusively due to malignancy.

Related Experiment Videos

Implications:

PTHrP production by non-malignant lymphoid tissue can occur in SLE.
This possibility should be considered in the differential diagnosis of hypercalcemia in SLE patients.
Highlights the need to consider non-oncologic causes for PTHrP elevation.