[Studies on human immunoglobulin preparations: I. Viral antibody profiles (author's transl)]

A study was undertaken to assess the viral antibody spectrum in human immunoglobulin preparations from four different manufacturers for intravenous and/or intramuscular application. Studies of the kind seem to be reasonable for calculating the expected therapeutic effect of the administered immunoglobulin. The investigated 16 gammaglobulin batches showed almost the same variety of viral antibodies and only slightly differring antibody titers. It is interesting to note, that antibodies to vaccinia virus could not be demonstrated. Quantitative determination of viral antibody titers in immunoglobulin preparations for standardization purposes should include the testing of antibodies to viruses against which a therapy with gammaglobulins is reasonable.