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Salivary gland involvement in systemic diseases
Otolaryngologic Clinics of North America
|June 1, 1977
Summary
Salivary glands can be affected by systemic diseases like mumps and Sjögren's syndrome, often causing gland enlargement. Diagnosis involves history, physical exam, and biopsy, with supportive care being the primary treatment.
Area of Science:
- Oral Medicine
- Pathology
- Immunology
Background:
- Salivary glands, as secretory organs linked to the gastrointestinal tract, are implicated in various systemic conditions.
- These conditions include inflammatory, allergic, and neoplastic diseases, impacting salivary gland function and structure.
Purpose of the Study:
- To elucidate the role of salivary glands in systemic illnesses.
- To highlight common conditions affecting salivary glands and diagnostic approaches.
Main Methods:
- Clinical observation and historical data review of patients with systemic diseases affecting salivary glands.
- Diagnostic criteria based on physical examination findings, including salivary gland enlargement.
- Biopsy of salivary glands (major or minor) or mucosal tissues for definitive diagnosis.
Main Results:
- Systemic involvement frequently leads to salivary gland enlargement, characterized by a tense, soft, and progressively growing gland.
- Mumps is a common acute condition, while Mikulicz's disease and Sjögren's syndrome are frequently noted chronic diseases.
- Bilateral and symmetrical salivary gland enlargement is a hallmark of systemic involvement.
Conclusions:
- Salivary gland involvement is a significant indicator of systemic disease, requiring careful clinical evaluation.
- While diagnosis can be aided by biopsy, definitive treatment for the underlying systemic illness is often challenging, necessitating supportive care.