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Effect of stromal cells from human lymph nodes on the growth of osteosarcoma cell lines
G Lisignoli1, S Toneguzzi, M C Monaco
1Laboratorio di Immunologia e Genetica, I.O.R., Bologna.
Bollettino Della Societa Italiana Di Biologia Sperimentale
|September 1, 1995
Abstract:
We investigated whether stromal cells obtained from human tonsils could interact and modulate the proliferation of the osteosarcoma cell in order to determine why lymph node metastases usually have a low incidence and remain occult using routine examinations. The effects of the supernatant of resting or activated stromal cells were analysed on osteoblastic cell proliferation of three different cell lines (HOS, U2, OS, MG-63). Only the proliferation of MG-63 was significantly inhibited. The direct adhesion of stromal cells to the osteosarcoma cell lines caused a greater inhibition of the proliferation of all three lines tested.