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[Intractable hiccup in two severely handicapped patients during phenytoin therapy]
1Department of Pediatrics, National Sanatorium, Nagara Hospital, Gifu.
No to Hattatsu = Brain and Development
|September 1, 1996
Abstract:
Two severely handicapped patients developed intractable hiccup during phenytoin therapy. In these two patients, serum phenytoin levels revealed 32.6 micrograms/ml and 17.6 micrograms/ml, respectively. Since large doses of phenytoin cause delayed latencies, and depressed or lost of brainstem auditory evoked potentials, it can be speculated that intractable hiccup could occur through dysfunction of brainstem by phenytoin.