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Related Experiment Videos

Vitamin E deficiency in variant angina

K Miwa1, Y Miyagi, A Igawa

  • 12nd Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.

Circulation
|July 1, 1996
PubMed
Summary

Patients with active variant angina have lower vitamin E levels, suggesting a link between vitamin E deficiency and coronary artery spasm. Supplementation with vitamin E acetate improved symptoms in some patients.

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Area of Science:

  • Cardiology
  • Nutritional Science
  • Biochemistry

Background:

  • Oxidative modification of low-density lipoprotein (LDL) may increase coronary vasoreactivity.
  • Vitamin E deficiency, a major antioxidant deficit, is potentially linked to coronary artery spasm occurrence.

Purpose of the Study:

  • To investigate plasma and LDL-fraction vitamin E levels in patients with variant angina.
  • To explore the relationship between vitamin E status and coronary artery spasm.
  • To assess the effect of vitamin E supplementation on angina symptoms.

Main Methods:

  • High-performance liquid chromatography was used to measure plasma and LDL-fraction alpha- and gamma-tocopherol levels.
  • Participants included patients with active variant angina, inactive variant angina, stable effort angina, and healthy controls.

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  • Vitamin E acetate supplementation was administered to a subset of patients with active angina.

    • Main Results:

    • Plasma alpha- and gamma-tocopherol levels, as well as alpha-tocopherol/lipids ratios, were significantly lower in patients with active variant angina compared to other groups.
    • Lower LDL-fraction alpha-tocopherol levels were observed in active variant angina patients.
    • Vitamin E levels increased, and angina occurrence decreased in patients supplemented with vitamin E acetate.

    Conclusions:

    • Significantly lower plasma vitamin E levels in active variant angina patients suggest an association between vitamin E deficiency and coronary artery spasm.
    • Vitamin E status may play a role in the pathophysiology of variant angina.
    • Vitamin E supplementation shows potential therapeutic benefits for managing variant angina.