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Related Experiment Videos

Cholesteryl ester transfer protein: an enigmatic protein

P Moulin1

  • 1Laboratoire de Métabolisme des Lipides, Hôpital de l'Antiquaille, Lyon, France.

Hormone Research
|January 1, 1996
PubMed
Summary

Cholesteryl ester transfer protein (CETP) moves cholesterol from HDL to VLDL, impacting lipid levels. Its role in atherosclerosis remains unclear, potentially being both pro- and anti-atherogenic.

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Area of Science:

  • Lipid Metabolism
  • Cardiovascular Research
  • Molecular Biology

Background:

  • Cholesteryl ester transfer protein (CETP) facilitates lipid transfer between lipoproteins.
  • CETP primarily interacts with high-density lipoproteins (HDL) and very-low-density lipoproteins (VLDL).
  • Its activity influences the composition of atherogenic apo B-containing lipoproteins.

Purpose of the Study:

  • To elucidate the multifaceted role of CETP in lipoprotein metabolism.
  • To investigate the correlation between CETP activity and lipid profiles in humans and experimental models.
  • To assess the controversial impact of CETP on atherosclerosis.

Main Methods:

  • Analysis of CETP activity in plasma and its association with lipoprotein composition.
  • Examination of CETP's effects in experimental models (e.g., transgenic mice).
  • Review of clinical studies on CETP gene mutations and their impact on HDL cholesterol.

Main Results:

  • CETP activity decreases HDL cholesterol and increases cholesteryl ester content in apo B-lipoproteins in experimental models.
  • In humans, CETP activity correlates positively with VLDL-LDL cholesterol, especially in hypertriglyceridemic states.
  • CETP gene mutations can lead to hyper-alpha-lipoproteinemia, but its effect on HDL in Caucasians is debated.

Conclusions:

  • CETP plays a complex role in lipid metabolism, potentially promoting atherogenesis by redistributing cholesterol.
  • Despite its involvement in reverse cholesterol transport, CETP's net effect on atherosclerosis requires further investigation.
  • CETP's influence on lipoprotein composition suggests a significant, yet not fully understood, impact on cardiovascular health.

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