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Updated: Sep 13, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
Published on: January 7, 2016
Nutritional regulation of the growth hormone and insulin-like growth factor-binding proteins
J M Ketelslegers1, D Maiter, M Maes
1Department of Internal Medicine, School of Medicine, Catholic University of Louvain, Brussels, Belgium.
Abstract:
Both growth hormone (GH) and insulin-like growth factors (IGFs) associate with specific binding proteins. Besides control by hormones, these binding proteins are nutritionally regulated. The GH-binding protein (GHBP) is the extracellular portion of the GH receptor. Its concentrations in circulation are decreased in severe malnutrition, reflecting a decrease in tissue GH receptor abundance. IGFs are bound to 6 different binding proteins (IGFBPs). IGFBP-3 is relatively stable and is only depressed after prolonged periods of severe malnutrition. In contrast, IGFBP-1 is regulated acutely by nutrient intake, showing major elevations after overnight fasting and rapid postprandial decreases. IGFBP-2 is highly dependent on dietary protein intake. Nutritional factors may regulate the tissue availability and the biological actions of IGFs by their actions on IGFBPs.
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