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[Life threatening salicylate poisoning caused by percutaneous absorption in severe ichthyosis vulgaris]

R Germann1, I Schindera, M Kuch

  • 1Hautarztpraxis, Völklingen.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|August 1, 1996
PubMed

Insights

Salicylate intoxication occurred in a child treated for ichthyosis vulgaris with topical salicylic acid ointment. Safer treatment options for ichthyosis vulgaris are needed.

Area of Science:

  • Dermatology
  • Toxicology
  • Pediatrics

Background:

  • Ichthyosis vulgaris is a common skin condition.
  • Topical salicylic acid is used to treat ichthyosis vulgaris.

Observation:

  • A 7-year-old boy developed salicylate intoxication after 4 weeks of topical 10% salicylic acid ointment.
  • Symptoms included somnolence, hyperventilation, vomiting, tinnitus, and vertigo.

Findings:

  • The patient presented with metabolic acidosis and a serum salicylate level of 985 micrograms/ml.
  • Treatment with forced diuresis and alkalization resolved the intoxication without hemodialysis.
  • Neurological deficits persisted for weeks, with full recovery taking 6 months.

Implications:

  • This case highlights the risk of salicylate toxicity from topical application in children.
  • It underscores the need for safer therapeutic alternatives for ichthyosis vulgaris in pediatric patients.

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