Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exercise and clenbuterol as strategies to decrease the progression of muscular dystrophy in mdx mice

E E Dupont-Versteegden1

  • 1Department of Physiology, University of Texas Health Science Center at San Antonio 78284-7756, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|March 1, 1996
PubMed
Summary

Exercise and clenbuterol show promise in slowing muscular dystrophy progression in mdx mice. However, clenbuterol combined with exercise increased fatigability and deformities, suggesting it may not be suitable for patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BOOSTing patient mobility and function on a general medical unit by enhancing interprofessional care.

Scientific reports·2021
Same author

Contribution of de novo point mutations to the overall mutational burden in mitochondrial DNA of adult rats.

Experimental gerontology·2005
Same author

Cycling exercise and fetal spinal cord transplantation act synergistically on atrophied muscle following chronic spinal cord injury in rats.

Neurorehabilitation and neural repair·2004
Same author

A rat resistance exercise regimen attenuates losses of musculoskeletal mass during hindlimb suspension.

Acta physiologica Scandinavica·2002
Same author

Molecular characteristics of aged muscle reflect an altered ability to respond to exercise.

International journal of sport nutrition and exercise metabolism·2002
Same author

Aged human muscle demonstrates an altered gene expression profile consistent with an impaired response to exercise.

Mechanisms of ageing and development·2000

Area of Science:

  • Biomedical Science
  • Exercise Physiology
  • Pharmacology

Background:

  • Muscular dystrophy is a progressive genetic disorder characterized by muscle degeneration.
  • Exercise is a known intervention for improving muscle function.
  • Clenbuterol is a beta-2 agonist with potential anabolic effects.

Purpose of the Study:

  • To investigate the effects of exercise and clenbuterol, alone and in combination, on the progression of muscular dystrophy in mdx mice.
  • To assess the impact on muscle function, morphology, and fatigability.

Main Methods:

  • mdx mice were assigned to sedentary, exercise, or combined exercise and clenbuterol groups.
  • Clenbuterol was administered orally, and exercise involved voluntary running.
  • Ventilatory function, muscle contractile properties, and morphology were analyzed at 3 months and 1 year of age.

Related Experiment Videos

Main Results:

  • Combined clenbuterol and exercise increased soleus muscle weight and protein content.
  • Both exercise and combined treatment improved normalized active tension in the diaphragm.
  • Absolute tetanic tension of the soleus increased with combined treatment, but fatigability also increased in both soleus and diaphragm muscles.

Conclusions:

  • Exercise and combined exercise with clenbuterol can decrease muscular dystrophy progression in mdx mice.
  • Different mechanisms underlie these effects, with clenbuterol leading to increased fatigability and deformities.
  • Clenbuterol may not be a suitable therapeutic agent for muscular dystrophy patients due to adverse effects.