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Changes in quantitative bone histomorphometry in aging healthy men

B L Clarke1, P R Ebeling, J D Jones

  • 1Division of Endocrinology, Mayo Clinic, Rochester, Minnesota 55905, USA.

The Journal of Clinical Endocrinology and Metabolism
|June 1, 1996
PubMed
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Age-related bone loss in healthy men involves decreased cancellous bone volume and osteoblast activity. Factors like androgens and body weight influence this decline, impacting bone mineral density at various skeletal sites.

Area of Science:

  • Gerontology
  • Bone Metabolism
  • Biochemistry

Background:

  • Age-related changes in bone mineral metabolism and their contributing factors in men are not well understood.
  • Quantitative bone histomorphometry provides insights into bone structure and remodeling processes.

Purpose of the Study:

  • To investigate age-related changes in bone histomorphometry in healthy men.
  • To identify biochemical and hormonal factors associated with age-related bone loss.

Main Methods:

  • Evaluated serum and urinary biochemical markers and iliac crest bone biopsies in 43 healthy men aged 20-80 years.
  • Utilized static and dynamic histomorphometric analysis to assess bone structure and turnover.
  • Performed univariate and multiple regression analyses to correlate histomorphometric parameters with biochemical data and bone mineral density (BMD).

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Main Results:

  • Cancellous bone volume and osteoblast-osteoid interface significantly decreased with age.
  • Dynamic parameters, including double and single labeled osteoid, also declined with aging.
  • Free androgen index and body weight were key predictors of age-related decline in cancellous bone volume.
  • Specific histomorphometric parameters predicted BMD at different skeletal sites, with cancellous bone volume being a significant predictor for lumbar spine, femoral neck, and total body BMD.

Conclusions:

  • Age-related bone loss in healthy men is characterized by reduced bone volume and impaired osteoblast function.
  • Hormonal factors, particularly androgens, play a crucial role in the pathogenesis of age-related bone loss.
  • Histomorphometric parameters are important determinants of BMD at various skeletal locations.