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[Auditory P300 in subjects in a post-anoxic coma. Preliminary data]

V Mutschler1, C G Chaumeil, L Marcoux

  • 1Service d'explorations fonctionnelles du système nerveux, hôpital de Hautepierrè, centre hospitalier universitaire, Strasbourg, France.

Neurophysiologie Clinique = Clinical Neurophysiology
|January 1, 1996
PubMed
Summary
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Auditory P300 event-related potentials show promise in predicting coma recovery. A positive P300 response in anoxic coma patients correlated with a higher chance of waking, aiding prognosis assessment.

Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Medical Prognostics

Background:

  • Event-related potentials, specifically the P300 component, are being explored for their prognostic value in comatose patients.
  • The etiology of coma significantly impacts prognosis, with anoxic coma generally having a less favorable outcome than traumatic coma.

Purpose of the Study:

  • To investigate the role of auditory P300 event-related potentials in predicting prognosis for patients with anoxic coma.
  • To evaluate the utility of P300 alongside traditional coma scales and other evoked potentials.

Main Methods:

  • Somatosensory evoked potentials, brainstem auditory evoked potentials, and P300 auditory event-related potentials were recorded in 20 anoxic coma patients.
  • Clinical status was assessed using the Glasgow, Liege, and Jouvet coma scales.

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Main Results:

  • Six out of twenty patients exhibited a positive P300 response; three of these patients subsequently awoke.
  • Of the 14 patients without a positive P300, only one awoke (5%), while 12 died and one remained in deep coma.

Conclusions:

  • Auditory P300 event-related potentials demonstrate potential as a valuable tool for prognostic assessment in anoxic coma.
  • P300 testing, in conjunction with clinical evaluation and other evoked potentials, may improve the accuracy of coma prognosis.