Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Auditory P300 in subjects in a post-anoxic coma. Preliminary data]

V Mutschler1, C G Chaumeil, L Marcoux

  • 1Service d'explorations fonctionnelles du système nerveux, hôpital de Hautepierrè, centre hospitalier universitaire, Strasbourg, France.

Neurophysiologie Clinique = Clinical Neurophysiology
|January 1, 1996
PubMed
Summary

Auditory P300 event-related potentials show promise in predicting coma recovery. A positive P300 response in anoxic coma patients correlated with a higher chance of waking, aiding prognosis assessment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Better Respiratory Education and Treatment Help Empower (BREATHE) study: Methodology and baseline characteristics of a randomized controlled trial testing a transitional care program to improve patient-centered care delivery among chronic obstructive pulmonary disease patients.

Contemporary clinical trials·2017
Same author

Early postoperative oral fluid intake in paediatric day case surgery influences the need for opioids and postoperative vomiting: a controlled randomized trial†.

British journal of anaesthesia·2017
Same author

Somatosensory evoked potentials in the assessment of peripheral neuropathies: Commented results of a survey among French-speaking practitioners and recommendations for practice.

Neurophysiologie clinique = Clinical neurophysiology·2015
Same author

Response to the letter by Vedran Deletis, David B. Mac Donald, Francesco Sala and Isabel Fernandez Conejero.

Orthopaedics & traumatology, surgery & research : OTSR·2014
Same author

Global Functional Disconnections in Post-anoxic Coma Patient.

The neuroradiology journal·2013
Same author

Intraoperative neurophysiologic monitoring in spine surgery. Developments and state of the art in France in 2011.

Orthopaedics & traumatology, surgery & research : OTSR·2013

Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Medical Prognostics

Background:

  • Event-related potentials, specifically the P300 component, are being explored for their prognostic value in comatose patients.
  • The etiology of coma significantly impacts prognosis, with anoxic coma generally having a less favorable outcome than traumatic coma.

Purpose of the Study:

  • To investigate the role of auditory P300 event-related potentials in predicting prognosis for patients with anoxic coma.
  • To evaluate the utility of P300 alongside traditional coma scales and other evoked potentials.

Main Methods:

  • Somatosensory evoked potentials, brainstem auditory evoked potentials, and P300 auditory event-related potentials were recorded in 20 anoxic coma patients.
  • Clinical status was assessed using the Glasgow, Liege, and Jouvet coma scales.

Related Experiment Videos

Main Results:

  • Six out of twenty patients exhibited a positive P300 response; three of these patients subsequently awoke.
  • Of the 14 patients without a positive P300, only one awoke (5%), while 12 died and one remained in deep coma.

Conclusions:

  • Auditory P300 event-related potentials demonstrate potential as a valuable tool for prognostic assessment in anoxic coma.
  • P300 testing, in conjunction with clinical evaluation and other evoked potentials, may improve the accuracy of coma prognosis.