[Severe pre-eclampsia in 3 generations. Case report on heritability of pre-eclampsia]

A case of pre-eclampsia/eclampsia appearing in three generations is presented combined with a review of literature. It is unknown whether the maternal genotype or the combination of the fetal and the maternal genotype is responsible for a disposition to this disease. Moreover the heredity as an autosomal-recessive or a dominant one with incomplete penetrance is in dispute. Further investigation will be convenient to improve the definition of groups at risk and a possible pharmacological prophylaxis.