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[Acute myocardial infarct and left ventricular dysfunction. Morphologic bases, clinical aspects and pharmacologic
1U.T.I.C - Arsénio Cordeiro, Hospital de Santa Maria/Faculdade de Medicina de Lisboa.
Insights
Left ventricular dysfunction after myocardial infarction is reviewed, focusing on prevention strategies. Angiotensin-converting enzyme inhibitors show promise in preventing left ventricular dysfunction post-myocardial infarction.
Area of Science:
- Cardiology
- Heart Failure Research
- Myocardial Infarction Studies
Abstract:
The morphological bases which condition left ventricular disfunction after acute myocardial infarction as well as the concepts of expansion and remodelling of the myocardium are reviewed. The clinical aspects indicating ventricular disfunction are presented and several pharmacological effects which have been proposed for the prevention of this situation. Particular emphasis is given to the role of angiotensin-converting enzyme inhibitors in the prevention of left ventricular disfunction after acute myocardial infarctions, based on the most recent clinical trials.