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Related Experiment Videos

[Prophylaxis of postoperative thromboembolism. Randomized prospective study]

L C Manso1, A Milheiro, F Castro e Sousa

  • 1Clínica Universitária de Propedeutica Cirúrgica, Faculdade de Medicina de Coimbra, Hospitais da Universidade de Coimbra.

Acta Medica Portuguesa
|February 1, 1996
PubMed
Summary

Non-fractionated heparin and low-molecular-weight heparin showed similar efficacy in preventing surgical complications. Low-molecular-weight heparin offers the advantage of once-daily administration.

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Area of Science:

  • Pharmacology
  • Thrombosis Research
  • Surgical Medicine

Background:

  • Heparin anticoagulants are crucial in preventing surgical thromboembolic events.
  • Non-fractionated heparin (UFH) and low-molecular-weight heparin (LMWH) are commonly used.
  • Comparative efficacy and safety data are essential for clinical decision-making.

Purpose of the Study:

  • To compare the efficacy and safety of UFH (Liquemine) versus LMWH (Fraxiparine) in surgical patients.
  • To evaluate differences in hemostasis, transfusion needs, and thromboembolic event rates.
  • To assess laboratory and clinical outcomes between the two heparin types.

Main Methods:

  • A comparative study involving 500 surgical patients, with 250 receiving UFH and 250 receiving LMWH.

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  • Monitoring included intraoperative and postoperative hemostasis, transfusion requirements, and clinical signs of deep vein thrombosis or pulmonary embolism.
  • Comprehensive laboratory analysis of blood (hemogram, biochemistry, coagulation) and urine was performed.

    • Main Results:

    • No statistically significant differences were observed between the UFH and LMWH groups regarding hemostasis difficulties, transfusion use, or thromboembolic events.
    • Laboratory parameters (hemogram, biochemistry, coagulation) and urine analysis showed comparable results between the two treatment groups.
    • Both heparin types demonstrated equivalent clinical effectiveness in the studied surgical population.

    Conclusions:

    • Non-fractionated heparin and low-molecular-weight heparin exhibit similar efficacy and safety profiles in the context of surgical procedures.
    • Low-molecular-weight heparin provides a significant advantage due to its simpler once-daily dosing regimen.
    • The choice between UFH and LMWH may be influenced by administration convenience and patient-specific factors.