Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Ropivacaine for spinal anesthesia. A dose-finding study]

W Wahedi1, H Nolte, P Klein

  • 1Institut für Anästhesiologie, Klinikum Minden.

Der Anaesthesist
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Meta-analyses of the efficacy of pharmacotherapies and sublingual allergy immunotherapy tablets for allergic rhinitis in adults and children.

Rhinology·2021
Same author

Deubiquitinase USP10 regulates Notch signaling in the endothelium.

Science (New York, N.Y.)·2019
Same author

Sugammadex hypersensitivity and underlying mechanisms: a randomised study of healthy non-anaesthetised volunteers.

British journal of anaesthesia·2018
Same author

Allergen exposure chambers: harmonizing current concepts and projecting the needs for the future - an EAACI Position Paper.

Allergy·2017
Same author

Dissociation of histamine releasing activity and T-cell reactivity of allergen conjugated with synthetic polymer.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2016
Same author

Safety of sublingual immunotherapy Timothy grass tablet in subjects with allergic rhinitis with or without conjunctivitis and history of asthma.

Allergy·2014

Ropivacaine at 0.5% and 0.75% concentrations provides effective spinal anesthesia in humans, with the higher concentration showing longer-lasting effects and motor block duration. This study establishes ropivacaine

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Clinical Trials

Background:

  • Ropivacaine's efficacy is established in epidural anesthesia but not extensively studied for spinal anesthesia in humans.
  • Previous research on ropivacaine for spinal anesthesia was limited to animal models.

Purpose of the Study:

  • To investigate the efficacy of isobaric ropivacaine for spinal anesthesia in human patients.
  • To determine the appropriate dosage of ropivacaine for effective spinal anesthesia.

Main Methods:

  • A randomized, double-blind study involving 40 patients divided into two groups.
  • Group I received 15 mg (0.5%) ropivacaine; Group II received 22.5 mg (0.75%) ropivacaine.
  • Sensory block assessed by cold sensation; motor block evaluated using the Bromage scale.

Related Experiment Videos

Main Results:

  • Both concentrations provided rapid onset of sensory analgesia, with no significant difference between groups.
  • The 0.75% ropivacaine group demonstrated significantly longer duration of sensory and motor block.
  • Adequate analgesia was not achieved in 20% of the 0.5% group, requiring additional analgesics or general anesthesia.
  • Motor block was complete in the 0.5% group, while incomplete in 30% of the 0.75% group, a significant difference.

Conclusions:

  • Isobaric ropivacaine at 0.5% and 0.75% concentrations is effective for long-lasting spinal anesthesia.
  • The 0.75% concentration offers a longer duration of sensory and motor blockade compared to the 0.5% concentration.