Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effects of buffer agents on postresuscitation myocardial dysfunction

S Sun1, M H Weil, W Tang

  • 1Institute of Critical Care Medicine, Palm Springs, CA 92262-5309, USA.

Critical Care Medicine
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histopathological aspects of dural arteriovenous fistulas in the transverse-sigmoid sinus region in nine patients.

Neurosurgery·1997
Same author

Expression of neurofibromatosis 2 protein in human brain tumors: an immunohistochemical study.

Acta neuropathologica·1997
Same author

Resting load and modulation of the myofilament Ca2+ sensitivity in rabbit cerebral arteries.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·1997
Same author

Current state of study on moyamoya disease in Japan.

Surgical neurology·1997
Same author

Antibodies to glutamic acid decarboxylase in Japanese diabetic patients with secondary failure of oral hypoglycaemic therapy.

Diabetic medicine : a journal of the British Diabetic Association·1997
Same author

Subdural hematoma.

Surgical neurology·1997
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Attracting Emergency Medicine Graduates to Surgical Critical Care Training Programs.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Beyond a Snapshot: Tracking Family Prognostic Expectations in the ICU.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure: Beware of Potential Confounders.

Critical care medicine·2026
See all related articles

Buffer agents administered during cardiopulmonary resuscitation (CPR) do not improve initial resuscitation success but significantly improve postresuscitation myocardial function and survival rates in animal models. These findings suggest a potential role for buffers in managing post-cardiac arrest complications.

Area of Science:

  • Cardiovascular Research
  • Critical Care Medicine
  • Pharmacology

Background:

  • Previous studies questioned the utility of buffer agents during cardiopulmonary resuscitation (CPR) due to lack of impact on myocardial pH or resuscitability.
  • Postresuscitation myocardial dysfunction is a critical factor influencing outcomes after successful cardiac resuscitation.

Purpose of the Study:

  • To evaluate the effects of buffer agents administered during CPR on postresuscitation myocardial function and survival.
  • To investigate the potential of buffers in mitigating myocardial dysfunction following resuscitation.

Main Methods:

  • A prospective, randomized, controlled animal study was conducted using male Sprague-Dawley rats.
  • Ventricular fibrillation was induced, followed by CPR after 4 or 8 minutes of untreated cardiac arrest.

Related Experiment Videos

  • Buffer agents (sodium bicarbonate, Carbicarb, tromethamine) or placebo were administered during CPR, with subsequent assessment of left ventricular function and survival for 240 minutes.

    • Main Results:

    • No differences in resuscitation success or electrical power required were observed between groups.
    • Postresuscitation left ventricular function was depressed in all animals, but less so with Carbicarb and tromethamine.
    • Both CO2-generating and CO2-consuming buffers improved myocardial function and survival, particularly after an 8-minute cardiac arrest interval.

    Conclusions:

    • Buffer agents administered during CPR do not enhance initial resuscitation success.
    • Buffers, including Carbicarb and tromethamine, can ameliorate postresuscitation myocardial dysfunction.
    • These agents may improve postresuscitation survival rates by mitigating cardiac dysfunction.