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Related Experiment Videos

Paroxetine in social phobia

C Mancini1, M V Ameringen

  • 1Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada.

The Journal of Clinical Psychiatry
|November 1, 1996
PubMed
Summary

Paroxetine, a selective serotonin reuptake inhibitor (SSRI), showed significant efficacy in treating social phobia. This open trial found that most patients experienced marked improvement in social anxiety and functioning.

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Pharmacology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) show promise for social phobia treatment.
  • Paroxetine is a novel SSRI investigated for its therapeutic potential.

Purpose of the Study:

  • To evaluate the efficacy of paroxetine in patients with generalized social phobia.
  • To assess paroxetine's impact on social anxiety, avoidance, and overall functioning.

Main Methods:

  • An open-label, 12-week clinical trial involving 18 patients diagnosed with social phobia.
  • Paroxetine dosage was adjusted based on patient response and tolerability.
  • Utilized various self-report and clinician-rated scales to measure social anxiety, depression, and functional outcomes.

Main Results:

  • All 18 participants completed the trial.
  • 83.3% of patients were classified as responders, indicating moderate to marked symptom improvement.
  • Statistically significant improvements were observed across all measures of social anxiety, avoidance, depression, and social functioning.

Conclusions:

  • Paroxetine demonstrates a potential role in treating generalized social phobia.
  • Further controlled studies are necessary to confirm these findings and compare paroxetine with other treatments.

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