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Studies on new antitumor antibiotics, leptofuranins A, B, C and D II. Physiocochemical properties and structure
1Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
The Journal of Antibiotics
|October 1, 1996
Abstract:
The structures of new antitumor antibiotics, leptofuranins A, B, C and D were elucidated to be as shown in Fig. 1 by NMR spectral analysis including a variety of two-dimensional techniques. The leptofuranins are novel leptomycin-related substances containing a tetrahydrofuran ring. Leptofuranins C and D were revealed to be in tautomeric isomerism and their relative stereochemistries were analyzed by NOESY experiments.