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Cholesterol and mental disorder

P F Boston1, S M Dursun, M A Reveley

  • 1Department of Psychiatry, Faculty of Medicine, University of Leicester.

The British Journal of Psychiatry : the Journal of Mental Science
|December 1, 1996
PubMed
Summary
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Serum cholesterol levels are linked to mental state and personality variations. Further research is needed to understand the connection between cholesterol and neurological function.

Area of Science:

  • Neuroscience
  • Biochemistry

Background:

  • Cholesterol is vital for cellular structure and function.
  • Serum cholesterol level changes may impact central nervous system neurotransmission.

Purpose of the Study:

  • To review the association between cholesterol levels and mental state.
  • To explore links to suicidal ideation, depression, personality, and schizophrenia.

Main Methods:

  • Conducted a MEDLINE literature search from 1990-1995.
  • Systematically searched citations and selected representative articles.
  • Focused on under-reviewed aspects like suicidal ideation, depression, personality, and schizophrenia.

Main Results:

  • Lowering cholesterol correlated with increased violent deaths in cardiovascular studies.

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  • Altered cholesterol levels are reported in various psychiatric disorders.

    • Conclusions:

    • Substantial evidence suggests serum cholesterol levels correlate with mental state and personality.
    • Further research is required to clarify these associations and underlying mechanisms.