Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Do you mind standing?: cognitive changes in orthostasis

L C Perlmuter1, J J Greenberg

  • 1Department of Psychology, Finch University of Health Sciences/Chicago Medical School, IL 60064, USA.

Experimental Aging Research
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Processing sets of letters for order: Evidence from reaction time experiments.

Memory & cognition·2011
Same author

Can infected composite mesh be salvaged?

Hernia : the journal of hernias and abdominal wall surgery·2010
Same author

Evaluating the benefits of patterned stimulation in the treatment of osteoarthritis of the knee: a multi-center, randomized, single-blind, controlled study with an independent masked evaluator.

Osteoarthritis and cartilage·2008
Same author

Survival after percutaneous endoscopic gastrostomy: the role of dementia.

The journal of nutrition, health & aging·2005
Same author

Postprandial systolic blood pressure and subsyndromal depression.

Experimental aging research·2001
Same author

Learned illness behavior and adjustment to arthritis.

Arthritis care and research : the official journal of the Arthritis Health Professions Association·2000
Same journal

SuperAgers Show Attenuated Age-Related Decline in Episodic Memory: Longitudinal Evidence from the Yakumo Study.

Experimental aging research·2026
Same journal

Mental Health Stereotypes and Aging: Effects on Mood and Decision Making.

Experimental aging research·2026
Same journal

Aging Reduces Attentional Modulation of Speech-Evoked Cortical Responses While Preserving Adaptation.

Experimental aging research·2026
Same journal

Ageing and Type of Employment Affect Workers' Ability to Anticipate Their Employment Prospects.

Experimental aging research·2026
Same journal

Associations of Self-Defining Memories Characteristics and Transdiagnostic Variables with Depressive Symptoms in Older Adults.

Experimental aging research·2026
Same journal

Older Adults Show Reduced High Frequency Power in Both Recent and Remote Spatial Memory Retrieval Compared to Younger Adults.

Experimental aging research·2026
See all related articles

Asymptomatic orthostatic hypotension, a condition affecting over 4% of older adults, is linked to cognitive decline. Lower systolic blood pressure upon standing predicts slower reaction times and impaired learning, highlighting a new factor in cognitive impairment.

Area of Science:

  • Neurology
  • Gerontology
  • Cardiology

Background:

  • Orthostatic hypotension (OH) can lead to cerebral hypoperfusion, potentially causing structural brain changes and cognitive impairment.
  • Cognitive function in individuals with asymptomatic orthostatic hypotension has not been extensively studied.
  • The prevalence of OH in the elderly population is significant, suggesting a potential public health concern.

Purpose of the Study:

  • To investigate the relationship between asymptomatic orthostatic hypotension and cognitive function in older adults.
  • To determine if reduced blood pressure upon standing is associated with specific cognitive deficits.

Main Methods:

  • Participants (55-74 years) with and without non-insulin-dependent diabetes mellitus underwent blood pressure and pulse measurements in supine and upright positions to assess orthostatic hypotension.

Related Experiment Videos

  • Cognitive function was evaluated approximately one hour after orthostatic hypotension assessment using standardized tests.
  • Statistical analyses controlled for potential confounders such as depression.

    • Main Results:

    • Decreased systolic blood pressure in response to upright posture was significantly associated with slower reaction times.
    • Impaired serial list learning was observed in individuals with greater blood pressure drops upon standing.
    • Immediate and working memory functions remained largely unaffected.

    Conclusions:

    • Asymptomatic orthostatic hypotension is a previously unrecognized contributor to cognitive decline in older adults.
    • Reduced cerebral perfusion due to orthostatic hypotension may underlie observed deficits in reaction time and learning.
    • Further research is warranted to explore the long-term cognitive consequences and potential interventions for orthostatic hypotension.