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Ketanserin in the treatment of protamine-induced pulmonary hypertension
P J van der Starre1, C Solinas
1Department of Cardiothoracic Anesthesiology and Intensive Care Hospital De Weezenlanden, Netherlands.
Texas Heart Institute Journal
|January 1, 1996
Abstract:
The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction. A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement. The potential role of serotonin in the development of this serious complication is discussed.