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RETRACTED: Cardiorespiratory changes in patients undergoing pulmonary resection using different anesthetic management
1From the Department of Anesthesiology and Intensive Care Medicine, and the Department of Surgery, Justus-Liebig-University Giessen, Ludwigshafen, Germany.
Journal of Cardiothoracic and Vascular Anesthesia
|December 1, 1996
Summary
Early extubation after lung cancer surgery with propofol anesthesia is safe for lobectomy patients, showing no negative cardiorespiratory effects. Pneumonectomy patients experienced sustained right ventricular dysfunction, unlike lobectomy patients.
Area of Science:
- Cardiorespiratory physiology
- Thoracic surgery anesthesia
Background:
- Pulmonary resection significantly alters cardiorespiratory function.
- The optimal anesthetic strategy for thoracic surgery remains undetermined.
Purpose of the Study:
- To compare cardiorespiratory effects of different anesthetic regimens and extubation timings in lung cancer surgery.
- To evaluate the safety of early extubation in lobectomy patients.
Main Methods:
- Prospective, randomized study of 50 lung cancer patients undergoing lobectomy or pneumonectomy.
- Hemodynamic monitoring including right ventricular function.
- Comparison of fentanyl/propofol/nitrous oxide/vecuronium with fentanyl/midazolam/vecuronium anesthesia and early vs. late extubation.
Main Results:
- Pneumonectomy caused significant right ventricular dysfunction and increased pulmonary pressures.
- Propofol anesthesia during one-lung ventilation (OLV) showed less compromise in oxygenation (PaO2/FiO2) compared to midazolam.
- Early extubation in lobectomy patients (propofol group) was safe with no adverse cardiorespiratory outcomes.
Conclusions:
- Pneumonectomy leads to more severe and prolonged right ventricular impairment.
- Propofol-based anesthesia may offer benefits during OLV in lobectomy.
- Early extubation is feasible and safe for lobectomy patients under propofol anesthesia.