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Evaluation of mixed venous oxygen saturation in chronic severe mitral regurgitation
Objective:
The objective of this study was to evaluate whether chronic severe mitral regurgitation leads to an artifactual elevation of mixed venous oxygen saturation.
Design:
Prospective study.
Setting:
University hospital setting.
Participants:
Thirty patients with chronic severe mitral regurgitation undergoing surgery on the mitral valve and 25 patients without mitral regurgitation scheduled for elective coronary artery surgery.
Interventions:
Blood samples were simultaneously withdrawn from the distal port and the paceport of a pulmonary artery catheter.
Measurements And Main Results:
During steady-state-anesthesia, oxygen saturation and hemoglobin concentration were measured. There was no difference between mean oxygen saturation in blood from the pulmonary artery and the right ventricle in patients with mitral regurgitation, no matter whether large v waves were present, and in patients without mitral regurgitation. The distribution of individual differences between mixed venous and right ventricular oxygen saturation did not differ between groups.
Conclusions:
Because mixed venous oxygen saturation is not affected by chronic severe mitral regurgitation, it can be used in patients with mitral regurgitation just as in patients without mitral regurgitation.