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Cd1a-positive cells in bronchoalveolar lavage samples from children with Langerhans cell histiocytosis
L Réfabert1, C Rambaud, T Mamou-Mani
1Service de Pneumologie et d'Allergologie Pédiatriques, Hôpital Necker-Enfants Malades, Paris, France.
The Journal of Pediatrics
|December 1, 1996
Abstract:
We evaluated CD1a-positive cells in bronchoalveolar lavage samples from children with Langerhans cell histiocytosis (LCH). All children with multifocal LCH and pulmonary symptoms scored higher than 5% (30.6% +/- 7.2%), whereas those with other lung disorders scored much less than 5%. In children with multifocal LCH, bronchoalveolar lavage fluid abnormalities can precede pulmonary symptoms. During chemotherapy the CD1a-positive cell count lends to decrease.