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Updated: Aug 15, 2026

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands
Published on: October 2, 2018
Actions of adrenomedullin on the rat adrenal cortex
1Department of Oral Pathology, St Bartholomew, London.
Abstract:
The actions of adrenomedullin on cAMP and aldosterone secretion have been investigated using an intact rat adrenal capsular preparation incubated in vitro. Adrenomedullin was found to cause a dose-dependent increase in aldosterone secretion, with a parallel increase in cAMP release. The minimum concentration of adrenomedullin required for significant stimulation of aldosterone secretion was 10nmol/l. Adrenomedullin did not affect ACTH-stimulated aldosterone secretion, but significantly inhibited endothelin-1 stimulated aldosterone secretion. We conclude that adrenomedullin is an aldosterone stimulant in the rat adrenal gland, acting through cAMP generation.
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