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A review of nonparametric tests for changepoint problems, with application to a recombinant drug therapy clinical
1Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037, USA.
Journal of Biopharmaceutical Statistics
|November 1, 1996
Abstract:
We review general classes of nonparametric tests for the changepoint problem. We extend these tests to analyze the results of a clinical trial examining whether pretreatment of surgical patients with erythropoietin reduces their subsequent need for blood transfusions. We find a changepoint in baseline hemoglobin levels, below which pretreatment with erythropoietin appears particularly beneficial relative to placebo.