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Related Experiment Videos

Variability in anticancer lignan levels in flaxseed

L U Thompson1, S E Rickard, F Cheung

  • 1Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada. lilian.thompson@utoronto.ca

Nutrition and Cancer
|January 1, 1997
PubMed
Summary

Flaxseed lignan levels vary significantly by variety and growing conditions. HPLC analysis can predict lignan production, crucial for cancer prevention research.

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Area of Science:

  • Nutritional Science
  • Food Chemistry
  • Cancer Research

Background:

  • Flaxseed lignans, like secoisolariciresinol diglycoside, show promise in preventing chemically induced cancers.
  • Flaxseed is the primary source of mammalian lignan precursors, but variability based on origin is unknown.

Purpose of the Study:

  • To investigate the impact of flaxseed variety, growing location, harvest year, and seeding time on lignan levels.
  • To assess mammalian lignan production through in vitro fermentation and quantify secoisolariciresinol using HPLC.

Main Methods:

  • Ten flaxseed varieties were analyzed for lignan production via in vitro fermentation with human fecal inoculum.
  • High-performance liquid chromatography (HPLC) was used to measure secoisolariciresinol content.
  • Three varieties were grown across multiple locations and harvest years, with varied seeding times.

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Main Results:

  • Significant variations in lignan production were found among flaxseed varieties (0.96–3.15 mumol/g).
  • Growing location significantly influenced lignan production for all tested varieties.
  • Harvest year affected lignan levels in one variety (Linott), while seeding time had no impact.

Conclusions:

  • Flaxseed lignan content is influenced by variety, growing location, and harvest year.
  • HPLC analysis is a reliable predictor of in vitro lignan production.
  • These factors must be considered in future cancer prevention studies utilizing flaxseed.