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Outbreak of multi-drug resistant Staphylococcus aureus: a cluster analysis
J Yoshida1, T Nagata, Y Nishioka
1Department of Surgery, National Shimonoseki Hospital, Japan.
Background:
Outbreaks of multi-drug resistant Staphylococcus aureus over eight years were investigated to prevent future endemic.
Methods:
Isolates of multiresistant S. aureus underwent a cluster analysis combined with canonical discriminant analysis using bacteriologic biotyping and sensitivity to 21 drugs.
Results:
Of a total of 786 strains recovered from 155 in-patients, the specialty surgical ward (SW) exhibited 470 isolates (59.8%) and the general SW 214 (27.2%). Among six clusters formed, four clusters were predominant in the general SW. An ordination diagram from the canonical discriminant analysis revealed a distribution in which clusters were localized temporally (year) and spatially (ward). A yearly shift of clusters indicated emergence of a new phenotype of multiresistant S. aureus.
Conclusions:
The cluster analysis of isolates of multiresistant S. aureus using biotyping and sensitivity may supplement the classical method of tracing the spreading patterns of this microbe.