Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The cardiac endothelium: cardioactive mediators

A M Shah1, R M Grocott-Mason, C B Pepper

  • 1Department of Cardiology, University of Wales College of Medicine, Cardiff, United Kingdom.

Progress in Cardiovascular Diseases
|November 1, 1996
PubMed
Summary

Cardiac endothelial cells release factors that regulate heart muscle contraction, primarily by altering myofilament properties, not calcium levels. This paracrine signaling impacts relaxation and diastolic tone, crucial for cardiac function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nrf2-mediated metabolic reprogramming drives regulatory T cell accumulation in hepatocellular carcinoma.

Nature communications·2026
Same author

Cost-effective genomic prediction for fertility traits: a comparison of machine learning and conventional models using low-coverage sequencing in Holstein heifers.

Animal : an international journal of animal bioscience·2026
Same author

Circulating dipeptidyl peptidase 3 and outcomes in acute heart failure: an analysis of the STRONG-HF and CORTAHF studies.

ESC heart failure·2026
Same author

Intraoperative Electroencephalography Alpha-Band Power Is a Better Proxy for Preoperative Low MoCA Under Propofol Compared With Sevoflurane.

Anesthesia and analgesia·2023
Same author

Impact of lockdown on cardiovascular disease hospitalizations in a Zero-COVID-19 country.

Public health·2023
Same author

A multi-centre retrospective study of Nocardia speciation and antimicrobial susceptibility in Queensland, Australia.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2023

Area of Science:

  • Cardiovascular Biology
  • Cardiac Physiology
  • Endothelial Cell Biology

Background:

  • Endothelial cells in the heart secrete various substances.
  • These substances modulate myocardial contractile function.
  • Known mediators include nitric oxide, endothelin, and prostanoids.

Purpose of the Study:

  • To investigate the mechanisms by which endothelial cells regulate cardiac function.
  • To elucidate the role of paracrine signaling in myocardial contractility.

Main Methods:

  • Bioassay studies to characterize endothelial-derived factors.
  • Analysis of the effects of these factors on cardiac myocyte properties.

Main Results:

  • Endothelial factors influence cardiac contractility predominantly by modifying myofilament properties.

Related Experiment Videos

  • Cytosolic Ca2+ transients are not the primary target of these modulations.
  • These actions disproportionately affect myocardial relaxation and diastolic tone.

    • Conclusions:

    • Paracrine modulation of cardiac myocytes by endothelial factors is a key regulatory mechanism.
    • This mechanism contributes to cardiac function in both physiological and pathological conditions.