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Related Experiment Videos

Oxandrolone in AIDS-wasting myopathy

J R Berger1, L Pall, C D Hall

  • 1Department of Neurology, University of Miami School of Medicine, Florida, USA.

AIDS (London, England)
|December 1, 1996
PubMed
Summary

Oxandrolone treatment improved weight and well-being in HIV-positive men with wasting syndrome. Higher doses may warrant further study, as muscle strength did not significantly improve at the doses used.

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Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Clinical Pharmacology

Background:

  • AIDS-associated wasting and myopathy significantly impact patient health.
  • Anabolic-androgenic steroids are being investigated for managing these conditions.

Purpose of the Study:

  • To evaluate the efficacy and safety of oxandrolone for treating AIDS-associated myopathy and wasting.

Main Methods:

  • A multicenter, double-blind, placebo-controlled study.
  • 63 HIV-seropositive men with significant weight loss were randomized.
  • Treatment groups received placebo, 5 mg/day, or 15 mg/day oxandrolone for 16 weeks.

Main Results:

  • Oxandrolone treatment led to weight gain or maintenance compared to placebo-induced weight loss.

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  • The 15 mg/day group reported increased appetite and activity.
  • No significant dose-related adverse events or laboratory abnormalities were observed.

    • Conclusions:

    • Oxandrolone (5-15 mg/day) positively impacted weight and well-being in HIV-associated wasting.
    • Muscle strength did not improve significantly at tested doses.
    • Oxandrolone was well-tolerated, suggesting further research with higher doses is warranted.