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Can elevated chromium induce somatopsychic responses?

I Lovrincevic1, F Y Leung, M A Alfieri

  • 1Department of Clinical Biochemistry, London Health Sciences Centre, Ontario, Canada.

Biological Trace Element Research
|October 1, 1996
PubMed
Summary
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Total parenteral nutrition (TPN) can significantly increase chromium (Cr) levels in patients, potentially causing somatopsychological effects. Further research is needed to assess Cr

Area of Science:

  • Trace metal toxicology
  • Nutritional biochemistry
  • Surgical patient care

Background:

  • Chromium (Cr) exposure is a concern for patients receiving total parenteral nutrition (TPN).
  • The somatopsychological effects of elevated serum Cr levels are not well understood.
  • Renal function was normal in the studied patient population.

Purpose of the Study:

  • To investigate the potential somatopsychological effects of chromium exposure in patients on TPN.
  • To measure serum chromium levels in patients receiving TPN.
  • To explore the relationship between elevated serum Cr and observed disturbances.

Main Methods:

  • Patient questionnaires assessing somatopsychological symptoms.
  • Biochemical analysis of serum chromium and other trace metals.

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  • Inclusion of patients with varying pathologies and TPN durations.

    • Main Results:

    • All patients on TPN exhibited elevated serum Cr levels, some up to 50-fold above normal.
    • No statistically significant relationship was found between increased serum Cr and somatopsychological disturbances.
    • One patient experienced significant dream disturbances, suggesting a potential link.

    Conclusions:

    • Chromium supplementation in short-term TPN is likely unnecessary due to contamination.
    • Long-term TPN with high chromium levels should be avoided due to potential genotoxicity.
    • Further investigation into chromium's somatopsychological effects, considering confounding factors like medications, is warranted.