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Genes, disease and medicine

C W Dykes1

  • 1Genomics Research Unit, Glaxo Wellcome Research and Development, Stevenage, UK.

British Journal of Clinical Pharmacology
|December 1, 1996
PubMed
Summary

Genomic research is revolutionizing disease study and drug development, enabling targeted therapies. However, widespread genetic testing raises concerns about understanding implications and ethical considerations.

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Area of Science:

  • Genomic medicine
  • Molecular diagnostics
  • Pharmacogenomics

Background:

  • Genomic research is transforming disease study, with the human genome project nearing completion.
  • Correlations between genetic mutations, disease susceptibility, and drug reactions are being established.
  • This progress facilitates the development of novel, targeted therapies for specific patient subsets.

Purpose of the Study:

  • To explore the impact of genomic research on disease study and targeted therapy development.
  • To address the challenges and opportunities presented by gene-based diagnostics in pharmaceutical development.
  • To highlight concerns regarding the rapid implementation of genetic testing.

Main Methods:

  • Analysis of current trends in genomic research and human genome sequencing.
  • Review of established correlations between genetic mutations and disease/drug responses.
  • Examination of the pharmaceutical industry's adaptation to targeted therapies.
  • Assessment of advancements in gene-based diagnostic technologies.

Main Results:

  • Genomic research is poised to identify major disease genes and enable targeted therapies.
  • Targeted therapies may reduce pharmaceutical markets but also development costs through efficient trials.
  • Gene-based diagnostics offer significant medical practice improvements.
  • Concerns exist about premature availability of genetic tests before full understanding of consequences.

Conclusions:

  • Genomic research promises revolutionary advancements in disease understanding and personalized medicine.
  • Targeted therapies offer a paradigm shift in drug development, balancing market size with efficiency.
  • The rapid progress in genetic testing necessitates careful consideration of biological, legal, ethical, and psychological implications.

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