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Multiple pleomorphic adenomas arising in the parotid and submandibular lymph nodes
M Shinohara1, T Ikebe, S Nakamura
1Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kyushu University, Fukuoka, Japan.
The British Journal of Oral & Maxillofacial Surgery
|December 1, 1996
Summary
This study details a rare case of multiple pleomorphic adenomas found in lymph nodes. These tumors likely originated from heterotopic salivary gland tissue within the lymph nodes.
Area of Science:
- Head and Neck Pathology
- Surgical Pathology
- Oncology
Background:
- Pleomorphic adenomas are the most common salivary gland tumors.
- Metastasis of pleomorphic adenomas is rare and typically associated with high mitotic activity and infiltration.
- Lymph node involvement by salivary gland tumors usually suggests metastasis.
Observation:
- A rare case of multiple pleomorphic adenomas occurred in the parotid and submandibular lymph nodes of a young male patient.
- Tumors were surrounded by lymphoid tissue resembling normal lymph node cortex.
- Associated heterotopic salivary gland tissue was identified within the affected lymph nodes.
Findings:
- Low mitotic activity and absence of infiltration discounted metastatic disease.
- Immunohistochemical staining of tumors mirrored that of heterotopic salivary gland tissue.
- These findings suggest a primary origin within the lymph nodes, not metastasis.
Implications:
- Pleomorphic adenomas can arise from ectopic salivary gland tissue within lymph nodes.
- This challenges the assumption that lymph node tumors of salivary gland origin are always metastatic.
- Highlights the importance of considering primary intralymphatic development in salivary gland pathology.