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Updated: Jul 26, 2026
08:53
Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
Rosette-forming non-Hodgkin's lymphomas
1Department of Pathology, Kaiser Foundation Hospital, Los Angeles, California, USA.
Histopathology
|December 1, 1996
Summary
Homer Wright rosettes, previously linked to neuroblastomas, can also appear in malignant lymphomas. This finding expands the differential diagnosis for rosette-forming small round cell tumors.
Area of Science:
- Oncology
- Pathology
Background:
- Homer Wright rosettes are characteristic of neuroblastomas and aid in diagnosing small round cell tumors.
- Their presence in lymph nodes or bone marrow traditionally ruled out malignant lymphoma.
Observation:
- This report details three cases of malignant lymphoma (two small lymphocytic, one diffuse large cell) exhibiting prominent rosette formation.
- The rosettes were composed of neoplastic lymphoid cells, sometimes with reactive macrophages, and featured a central fibrillary core.
Findings:
- Two lymphomas were B-cell lineage, and one was T-cell lineage, marking the first reported instance of T-cell lymphoma with rosettes.
- Ultrastructural analysis revealed interdigitating cytoplasmic projections within the rosettes.
Implications:
- Malignant lymphomas, particularly non-Hodgkin's lymphoma, should be considered in the differential diagnosis of neoplasms with rosette formation.
- This challenges previous diagnostic assumptions and broadens the understanding of lymphoma morphology.
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