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Hyperhomocysteinemia and deep-vein thrombosis. A case-control study

P Simioni1, P Prandoni, A Burlina

  • 1Institute of Medical Semeiotics, University Hospital of Padua, Italy.

Thrombosis and Haemostasis
|December 1, 1996
PubMed
Summary

High homocysteine levels are significantly linked to deep-vein thrombosis (DVT) in patients experiencing symptoms. This study found a 2.6 times higher odds of DVT in individuals with hyperhomocysteinemia.

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Area of Science:

  • Cardiology
  • Hematology
  • Clinical Medicine

Background:

  • Deep-vein thrombosis (DVT) is a significant clinical concern.
  • Elevated homocysteine levels have been investigated as a potential risk factor for thrombotic events.

Purpose of the Study:

  • To investigate the association between fasting total homocysteine levels and the presence of deep-vein thrombosis (DVT) in symptomatic outpatients.

Main Methods:

  • A case-control study was conducted on 208 outpatients suspected of having a first episode of lower limb DVT.
  • Fasting total homocysteine levels were measured.
  • Contrast venography was used to confirm or exclude DVT.

Main Results:

  • DVT was confirmed in 60 patients (28.8%).

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  • Hyperhomocysteinemia was present in 25.0% of patients with DVT versus 11.5% of those without DVT (p = 0.025).
  • The odds ratio for acute DVT in patients with hyperhomocysteinemia was 2.6 (95% CI: 1.1-5.9).

    • Conclusions:

    • High plasma homocysteine levels are significantly associated with acute deep-vein thrombosis in symptomatic patients.
    • Further research is warranted to understand the clinical implications of this association.