Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solubility principles and practices for parenteral drug dosage form development

S Sweetana1, M J Akers

  • 1Pharmaceutical Sciences, Lilly Research Laboratories, Indianapolis, Indiana, USA.

PDA Journal of Pharmaceutical Science and Technology
|September 1, 1996
PubMed
Summary

Formulating intravenous drugs with poor water solubility is challenging. This review aids scientists by summarizing literature and providing data, though further research is needed for predictable solubilization methods.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drugs of the future: lessons of the past.

Pharmaceutical development and technology·2001
Same author

The degradation of the antitumor agent gemcitabine hydrochloride in an acidic aqueous solution at pH 3.2 and identification of degradation products.

Journal of pharmaceutical sciences·2000
Same author

Acute and long-term stability studies of deoxy hemoglobin and characterization of ascorbate-induced modifications.

Journal of pharmaceutical sciences·1999
Same author

The physical state of mannitol after freeze-drying: effects of mannitol concentration, freezing rate, and a noncrystallizing cosolute.

Journal of pharmaceutical sciences·1998
Same author

Glycine crystallization during freezing: the effects of salt form, pH, and ionic strength.

Pharmaceutical research·1995
Same author

Sterility testing of antimicrobial-containing injectable solutions prepared in the pharmacy.

American journal of hospital pharmacy·1991

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Formulation Development

Background:

  • Solubilizing poorly water-soluble drugs for intravenous administration presents significant challenges in parenteral formulation.
  • Existing methods often rely on empirical approaches due to a lack of complete understanding of drug-solubilizer interactions.

Purpose of the Study:

  • To review existing literature on parenteral drug solubilization techniques.
  • To provide tabular data to assist formulation scientists in addressing solubility challenges.
  • To highlight the need for further research into predictive models for drug solubilization.

Main Methods:

  • Literature review of parenteral drug solubilization strategies.
  • Compilation and presentation of relevant data in tabular format.

Related Experiment Videos

Main Results:

  • A summary of key literature findings related to parenteral drug solubilization.
  • Tabular information designed to aid formulation scientists in practical problem-solving.
  • Identification of the empirical nature of current solubilization practices.

Conclusions:

  • Parenteral drug solubilization remains a complex and often empirical process.
  • Improved understanding and predictive models for interactive solvent systems are crucial.
  • Significant opportunities exist for scientific advancement in parenteral drug formulation.