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TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor
1Department of Anatomy and Cell Biology, University of Toronto, Ont., Canada. bjerknes@crypt.med.utoronto.ca
Gene
|November 28, 1996
Summary
The transcription factor like 4 (TCFL4) gene structure was detailed in humans, alongside its mouse cDNA sequences. This widely expressed gene shows high protein conservation between species.
Area of Science:
- Genetics
- Molecular Biology
- Gene Expression
Background:
- TCFL4 (transcription factor like 4) encodes a widely expressed putative basic helix-loop-helix leucine-zipper (bHLH-zip) transcription factor.
- The TCFL4 gene is located at 17q21.1, downstream of the HSD17B1 gene and centromeric to the BRCA1 locus.
Purpose of the Study:
- To report the human gene structure of TCFL4.
- To determine the murine cDNA sequence of TCFL4 variants.
Main Methods:
- Human gene structure analysis.
- Murine cDNA sequencing of TCFL4 variants.
Main Results:
- Detailed human TCFL4 gene structure was elucidated.
- Two murine TCFL4 cDNA variants, approximately 1.5 kb and 2.2 kb, were sequenced.
- The deduced TCFL4 protein sequence demonstrated high conservation between human and mouse.
Conclusions:
- The study provides foundational information on the human TCFL4 gene structure and its murine counterparts.
- High conservation of the TCFL4 protein suggests important conserved functions across species.