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Related Experiment Videos

RANTES in onchocerciasis: changes with ivermectin treatment

P J Cooper1, R H Guderian, D Prakash

  • 1Division of Infectious Diseases, St George's Hospital Medical School, London, UK.

Clinical and Experimental Immunology
|December 1, 1996
PubMed
Summary

Ivermectin treatment for onchocerciasis can cause adverse reactions. Researchers found that RANTES levels may influence eosinophil sequestration, potentially impacting reaction severity.

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Area of Science:

  • Immunology
  • Parasitology
  • Pharmacology

Background:

  • Onchocerciasis treatment with ivermectin frequently causes adverse reactions.
  • Chemokines like RANTES and IL-8, and cytokines TNF-alpha and IL-6, are implicated in post-treatment reactions.
  • Understanding these inflammatory mediators is crucial for managing ivermectin side effects.

Purpose of the Study:

  • To investigate the role of specific chemokines and cytokines in the pathogenesis of ivermectin-induced adverse reactions in onchocerciasis patients.
  • To measure circulating levels of RANTES, IL-8, TNF-alpha, and IL-6 following ivermectin administration.
  • To correlate these levels with clinical manifestations such as rash and lymphoedema.

Main Methods:

  • Plasma samples were collected from 22 subjects infected with Onchocerca volvulus before and at various time points after ivermectin treatment.

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  • Circulating levels of RANTES, IL-8, TNF-alpha, and IL-6 were quantified.
  • Peripheral eosinophil counts and clinical signs of adverse reactions (rash, lymphoedema) were assessed.

    • Main Results:

    • Peak circulating levels of RANTES and TNF-alpha were observed at 6 hours post-ivermectin administration.
    • An early peak in RANTES levels correlated with a delayed decrease in peripheral eosinophil counts.
    • Higher circulating RANTES levels were significantly associated with reduced severity of rash and lymphoedema.

    Conclusions:

    • Circulating RANTES may play a significant role in modulating eosinophil sequestration in vivo during ivermectin treatment for onchocerciasis.
    • The findings suggest RANTES could be a key factor in the inflammatory response and severity of adverse reactions.
    • No significant changes were observed in circulating IL-8 levels.