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Thyroid function and immune profile in rheumatoid arthritis. A controlled study

A P Andonopoulos¹, V Siambi, M Makri

¹Department of Medicine, University of Patras School of Medicine, Greece.

Clinical Rheumatology

|November 1, 1996

Summary

Rheumatoid arthritis patients show a higher prevalence of thyroid dysfunction and autoimmune thyroiditis compared to controls. However, no significant association was found between thyroid issues and rheumatoid arthritis serologic findings or D-penicillamine use.

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Area of Science:

Endocrinology
Rheumatology
Immunology

Background:

Rheumatoid arthritis (RA) is an autoimmune disease associated with various extra-articular manifestations.
Thyroid dysfunction and autoimmune thyroiditis are more common in patients with autoimmune diseases.

Purpose of the Study:

To determine the prevalence of thyroid dysfunction and autoimmune abnormalities in RA patients.
To investigate the potential association between D-penicillamine and autoimmune thyroiditis in RA patients.

Main Methods:

Prospective study of 101 RA patients and 70 age/sex-matched controls.
Evaluation included clinical assessment, serologic profiles, and thyroid function tests (T4, T3, TSH, AbTPO, TRAB).
Free T3/T4 and TBG levels were measured in specific subgroups.

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Main Results:

RA patients exhibited higher rates of thyroid dysfunction (9.9%) and subclinical autoimmune thyroiditis (12.9%) than controls (5.7% and 8.6%).
No significant association was found between thyroid abnormalities and RA serologic markers.
The incidence of autoimmune thyroiditis was similar in RA patients who received or did not receive D-penicillamine.

Conclusions:

RA patients have a notable prevalence of thyroid dysfunction and subclinical autoimmune thyroiditis.
Thyroid dysfunction in RA is not significantly correlated with RA disease activity markers or D-penicillamine treatment.
Further research may be warranted to elucidate the complex interplay between RA and thyroid autoimmunity.