Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glutamine: from basic science to clinical applications

T R Ziegler1, E E Szeszycki, C F Estívariz

  • 1Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Nutrition (Burbank, Los Angeles County, Calif.)
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: The effect of a single, large bolus of vitamin D in healthy adults over the winter and following year: a randomized, double-blind, placebo-controlled trial.

European journal of clinical nutrition·2023
Same author

The effect of a single, large bolus of vitamin D in healthy adults over the winter and following year: a randomized, double-blind, placebo-controlled trial.

European journal of clinical nutrition·2014
Same author

Outcomes of percutaneous endoscopic gastrostomy in hospitalized patients at a tertiary care center in Turkey.

European journal of clinical nutrition·2014
Same author

Effects of high-dose cholecalciferol on serum markers of inflammation and immunity in patients with early chronic kidney disease.

European journal of clinical nutrition·2013
Same author

Incidence and prevalence of copper deficiency following roux-en-y gastric bypass surgery.

International journal of obesity (2005)·2011
Same author

Providing monovalent oral polio vaccine type 1 to newborns: findings from a pilot birth-dose project in Moradabad district, India.

Bulletin of the World Health Organization·2010
Same journal

Different approaches of strength-to-muscle mass ratio: impact on 24-month outcomes in patients with acute coronary syndrome.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
Same journal

From scriptural reference to scientific evidence a critical review of the nutritional composition and functional food potential of foods described in classical Islamic texts.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
Same journal

Integrating BIA-derived body composition parameters with GLIM criteria for survival prediction in patients with solid tumors.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
Same journal

Polyunsaturated fatty acids in the prevention, treatment, and survival of breast cancer.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
Same journal

Unpacking the eating pathways: The mediating roles of emotional eating and problem-solving skills in the relationship between childhood trauma and eating expectancies.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
Same journal

Improving communication about dietary fats: development and validation of the Fats-Related Attitude Scale based on data from Brazil, China, Croatia, Poland, and Spain.

Nutrition (Burbank, Los Angeles County, Calif.)·2026
See all related articles

Glutamine (Gln) supplementation shows promise in supporting catabolic patients, improving organ function and reducing infection rates. Further research will clarify its role as a conditionally essential nutrient in human nutrition support.

Area of Science:

  • Nutrition Science
  • Clinical Nutrition
  • Amino Acid Metabolism

Background:

  • Glutamine (Gln) is a key nutrient for gut mucosa and immune cells.
  • Animal studies indicate Gln supplementation benefits organ function and survival during catabolic stress.
  • Emerging research elucidates Gln's molecular mechanisms in various cells and organs.

Purpose of the Study:

  • To review the evidence for Glutamine (Gln) supplementation in nutrition support.
  • To assess the safety and efficacy of Gln-enriched nutrition in catabolic patients.
  • To explore the role of Gln as a conditionally essential nutrient in humans.

Main Methods:

  • Review of animal studies on Gln supplementation in catabolic stress models.
  • Analysis of double-blind, prospective clinical trials of Gln-enriched enteral and parenteral nutrition.

Related Experiment Videos

  • Examination of molecular and protein chemistry studies on Gln's mechanisms of action.

    • Main Results:

    • Gln supplementation improved organ function and survival in animal models.
    • Gln-enriched nutrition is generally safe and effective in catabolic patients.
    • Intravenous Gln increased plasma Gln levels, promoted anabolism, and reduced morbidity (e.g., infections, hospital stay).

    Conclusions:

    • Glutamine (Gln) is an important dietary nutrient.
    • Gln is likely conditionally essential in humans during specific catabolic conditions.
    • Further clinical studies are needed to establish routine Gln supplementation protocols.