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Raynaud's phenomenon and systemic sclerosis

S Generini1, B Kahaleh, M Matucci-Cerinic

  • 1Istituto di Clinica Medica IV, Università degli Studi di Firenze.

Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna
|April 1, 1996
PubMed
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Systemic sclerosis causes Raynaud's phenomenon, characterized by vasospasm. A sensory nervous system failure may lead to unopposed endothelial and platelet activity, driving this vasospasm and contributing to vascular disease.

Area of Science:

  • Vascular Biology
  • Rheumatology
  • Pathophysiology

Background:

  • Systemic sclerosis (SSc) is associated with Raynaud's phenomenon (RP), a vasospastic disorder.
  • RP in SSc involves digital arterial closure and inadequate vasodilation, affecting extremities and internal organs.
  • Repeated RP attacks may cause endothelial reperfusion injury and fibrosis in SSc.

Purpose of the Study:

  • To reconsider the pathogenetic process of Raynaud's phenomenon in systemic sclerosis.
  • To investigate the role of neuropeptides, vascular endothelium, and platelets in vascular tone control.
  • To explore the hypothesis of sensory nervous system failure in SSc-associated RP.

Main Methods:

  • Review of recent advances in vascular tone control mechanisms.

Related Experiment Videos

  • Hypothesis formulation based on current understanding of endothelial, platelet, and nervous system interactions.
  • Proposed investigation into local vascular mediators in vasospasm.

    • Main Results:

    • Vascular tone is controlled by neuropeptides, endothelium, and platelets.
    • A proposed mechanism involves sensory nervous system failure leading to unopposed endothelial and platelet function.
    • Endothelial injury and platelet activation in SSc shift vascular function towards a pro-vasospastic state.

    Conclusions:

    • Sensory nervous system failure is hypothesized as a key factor in SSc-associated Raynaud's phenomenon.
    • Dysfunctional vascular tone control, with enhanced vasospasm, contributes to SSc pathophysiology.
    • Understanding local vascular mediators is crucial for unraveling RP pathophysiology in SSc.