The "Tor Vergata" epidemiological blood pressure study. Hereditary and environmental factors

The aim of this study was to evaluate the influence of hereditary and/or environmental factors on blood pressure patterns. The study group consisted of 1002 individuals. Comparison of blood pressure values among groups was performed by the Bravais-Pearson r correlation coefficient. Results among the different groups were: p < 0.001 in the parents-offspring group (n = 413) for both systolic (SBP) and diastolic blood pressure (DBP); p < 0.001 in the father-offspring group (n = 382) for SBP only; p < 0.001 in the mother-offspring group (n = 389) for both SBP and DBP; NS in the father-son group (n = 199) for any blood pressure value; p < 0.01 in the father-daughter group (n = 183) for SBP only; p < 0.001 in the mother-son and daughter groups (n = 201 and n = 188 respectively) for both SBP and DBP. Family aggregation analysis disclosed p < 0.01 and p < 0.05 for SBP and DBP respectively in the mother-her sibling group. No significant values were found in the father-his sibling group or between offspring and either their paternal or maternal uncles/aunts. Conversely, a significant correlation (p < 0.001) was found between spouses (fathers and mothers) for both SBP and DBP. These results support the hypothesis that both hereditary and environmental factors exert their influence on blood pressure patterns. We performed both univariate and bivariate statistical analyses. The latter included a) variable separation, b) independent variables, and c) variable correlation. Bivariate analysis of variable correlation proved to be the most suitable.